Ammonia methanol → 3-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:14]OS(C)(=O)=O)[C:5]([CH2:8]OS(C)(=O)=O)=[N:6][CH:7]=1.CO.[NH3:22]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:14][NH:22][CH2:8][C:5]2=[N:6][CH:7]=1参加物
4
実験手順
To a solution of 58 (1 g, crude) in MeOH (5 mL) was added MeOH—NH3 (5 mL) at 0° C. and stirred at rt for overnight. The reaction mixture was evaporated to obtain the desired compound (600 mg, crude) as a brown liquid. Rf: 0.2 (10% MeOH/CHCl3). The crude compound was used in the next step without further purification; (m/z): 199, 201 [MH]+.
後処理
- customThe reaction mixture was evaporated
出典と根拠
- ORDレコード
- ord-83947362e9ab4d02aff7a4206acc85c4
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09433622B2
反応ノート
読み込み中…