Sodium Bicarbonate → (5-Bromo-6-methoxypyridin-2-yl)methanol
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]C(OC)=O)=[N:6][C:7]=1[O:8][CH3:9].C([O-])(O)=[O:16].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][OH:16])=[N:6][C:7]=1[O:8][CH3:9]参加物
4
実験手順
step d—A solution of 52c (0.060 g), 5% aq. NaHCO3 (2 mL) and MeOH (2 mL) was heated at reflux for 2 h. The reaction mixture was partitioned between H2O and EtOAc and the combined EtOAc extracts were dried, filtered and evaporated in vacuo. The crude product was purified by SiO2 chromatography eluting with 25% EtOAc/hexane to afford 50a.
後処理
- temperatureat reflux for 2 h
- customThe reaction mixture was partitioned between H2O and EtOAc
- dry with materialthe combined EtOAc extracts were dried
- filtrationfiltered
- customevaporated in vacuo
- customThe crude product was purified by SiO2 chromatography
- washeluting with 25% EtOAc/hexane
出典と根拠
- ORDレコード
- ord-904fb98201924644aa45b8339ea0dcc1
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063072B2
反応ノート
読み込み中…