Potassium Carbonate → (E)-4-(2,4-difluorophenyl)but-3-en-2-one
反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.COP([CH2:17][C:18](=[O:20])[CH3:19])(=O)OC.C([O-])([O-])=O.[K+].[K+]>O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:17]/[C:18](=[O:20])[CH3:19]参加物
5
反応条件
- 温度
- 0 °C
実験手順
A two necked flask was charged with 2,4-difluorobenzaldehyde (4.0 g, 28.1 mmol) and (2-oxo-propyl)-phosphonic acid dimethyl ester (5.78 g, 33.0 mmol) and cooled down at 0° C. K2CO3 (7.62 g, 55.1 mmol) in H2O (14 mL) was added dropwise. Stirring was continued over night at RT. The product was extracted with EtOAc, and the organic phase was dried over Na2SO4. Flash chromatography (SiO2, Heptane/EtOAc 1:3) afforded 4.0 g (79%) of the title compound as alight yellow oil.
後処理
- waitwas continued over night at RT
- extractionThe product was extracted with EtOAc
- dry with materialthe organic phase was dried over Na2SO4
出典と根拠
- ORDレコード
- ord-54f77850b0b7448d92f18ca0bbf4f00d
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063075B2
反応ノート
読み込み中…