Hydrochloric Acid → (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride

HRID 559333ノート

反応式

HRID 559333 の反応式
C(OC([N:8]1[CH2:15][CH2:14][C:11]2([CH2:13][CH2:12]2)[C@H:10]([OH:16])[CH2:9]1)=O)(C)(C)C.[ClH:17].COC(C)(C)C>C(O)C>[ClH:17].[CH2:12]1[C:11]2([CH2:14][CH2:15][NH:8][CH2:9][C@H:10]2[OH:16])[CH2:13]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 15413tert-Butyl methyl etherHCID 66783172tert-Butyl (S)-4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate

生成物 1

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of (S)-4-hydroxy-6-aza-spiro[2.5]octane-6-carboxylic acid tert-butyl ester (3.26 g, 14.3 mmol) in ethanol (10 ml) was treated at room temperature with hydrogen chloride solution (4 M in 1,4-dioxane, 30 ml), then after 1 h tert-butyl methyl ether (40 ml) was added. The suspension was stirred for 1 h, then the precipitate was collected by filtration to afford the title compound (2.11 g, 90%). White solid, MS: 128.1 (M+H)+.

後処理

  1. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-16cf333efc3743c0bd98b60a5016a15d
出典データセット
uspto-grants-2011_11
特許番号
US08063042B2

反応ノート

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