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N-((9H-Fluoren-9-ylmethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteine → Fmoc-Cys(Trt)-OMe
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-((9H-Fluoren-9-ylmethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteine | HCID 128239 | — |
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Fmoc-Cys(Trt)-OMe | HCID 59278482 | — |
反応手順
To a stirred solution of Fmoc-L-Cys(Trt)-OH (2.34 g, 4.00 mmol) in methanol (4.0 mL) and benzene (16 mL) was added TMS-diazomethane (2.40 mL, 4.80 mmol). After 1 hour, the mixture was concentrated in vacuo to afford Fmoc-L-Cys(Trt)-OMe which was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063065B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-c83cab7fd06241daad4611fb6fdeb1af |
| 出典メモ | uspto-grants-2011_11 |