Potassium Carbonate → 5-(Methylthio)-2-pyridinecarbonitrile

HRID 559823ノート

反応式

HRID 559823 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:10][S-:11].[Na+].C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[CH3:10][S:11][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 8171545-Bromopyridine-2-carbonitrileHCID 4378561Sodium methanethiolate

生成物 1

HCID 594558745-(Methylthio)-2-pyridinecarbonitrile収率 99%

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

5-Bromo-pyridine-2-carbonitrile (2.63 g, 13.7 mmol), sodium methanethiolate (1.44 g, 20.5 mmol), potassium carbonate (3.79 g, 27.4 mmol) in NMP (60 ml) were stirred in a sealed flask overnight. The mixture was partitioned between ethyl acetate and water. The organic phase was washed with water several times, brine and dried over sodium sulphate. The solvent was removed in vacuo to afford the title compound as a yellow solid (2.0 g, 99%).

後処理

  1. customThe mixture was partitioned between ethyl acetate and water
  2. washThe organic phase was washed with water several times, brine
  3. dry with materialdried over sodium sulphate
  4. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-20d66210a3aa46b0bf8d422381d632dc
出典データセット
uspto-grants-2011_11
特許番号
US08063073B2

反応ノート

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