化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 反応物 | 2-(2,3-Dimethoxyphenoxy)-5-fluoroaniline | HCID 66998831 | — |
| 生成物 | N-[2-(2,3-Dimethoxyphenoxy)-5-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59733076 | 65% |
| 生成物 | 2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene | HCID 66999058 | 68% |
反応手順
2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene (1.0 g, 68%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-5-fluoro-aniline (0.67 g, 75%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-5-fluoro-phenyl]-N′-(thiazol-2-yl)urea (126 g, 65%) was prepared from 2-(2,3-dimethoxyphenoxy)-5-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063081B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-4bb1c02b54224632914a81ec19ebd2c7 |
| 出典メモ | uspto-grants-2011_11 |