化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → Methyl 2-(2-nitrophenylthio)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | Methyl 2-[(2-aminophenyl)sulfanyl]benzoate | HCID 614949 | — |
| 生成物 | Methyl 2-(2-nitrophenylthio)benzoate | HCID 57362693 | 80% |
| 生成物 | N-[2-(2-Methoxycarbonylphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea | HCID 59733061 | 74% |
反応手順
2-(2-Methoxycarbonylphenylsulfanyl)nitrobenzene (1.15 g, 80%) was prepared from methyl thiosalicylate (0.92 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-methoxycarbonyl-phenylsulfanyl)aniline (0.75 g, 73%) following the general procedure B. N-[2-(2-Methoxycarbonylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (142 mg, 74%) was prepared from 2-(2-methoxycarbonylphenylsulfanyl)aniline (130 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063081B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-9e932a8539694bd4bb5e2ec9995396e9 |
| 出典メモ | uspto-grants-2011_11 |