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Sodium Carbonate → 3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-(Dihydroxyboranyl)benzoic acid | HCID 2733985 | — |
| 反応物 | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one | HCID 67001148 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 3'-(1-Benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-2-carboxylic acid | HCID 44547894 | — |
反応手順
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-phenyl-imidazolidin-2-one (example 5, step 2) was reacted with 2-carboxyphenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-2-oxo-3-phenyl-imidazolidin-4-yl)-biphenyl-2-carboxylic acid as an off-white solid. MS: 497.1 ([M−H]−)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063088B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-153d4931ed724790bfa0c67dd7aa8592 |
| 出典メモ | uspto-grants-2011_11 |