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Sodium hydride → 3-Isopropyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 5-Methyl-1,2-oxazole-4-sulfonyl chloride | HCID 2776141 | — |
| 反応物 | 1-Isopropyl-5-(3'-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one | HCID 67000948 | — |
| 生成物 | 3-Isopropyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one | HCID 44548042 | — |
反応手順
In analogy to example 13, step 2,1-isopropyl-5-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one (example 13, step 1) was reacted with sodium hydride and 5-methyl-4-isoxazolesulfonyl chloride to give 3-isopropyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one as a light brown solid. MS: 502.4 ([M−H]−)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063088B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-24809f6d131642a18f1b52cde79241cb |
| 出典メモ | uspto-grants-2011_11 |