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Sodium Carbonate → 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3-(Aminosulphonyl)benzeneboronic acid | HCID 44119323 | — |
| 反応物 | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide | HCID 67001072 | — |
反応手順
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 3-boronobenzenesulfonamide in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide as a colorless solid. MS: 499.9 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063088B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-242f97bfa5994943abcfaa83ab56936b |
| 出典メモ | uspto-grants-2011_11 |