1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid → (1S,2S,5R)-2-{[(2-Ethyl-5-methyl-2H-pyrazole-3-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

HRID 560345ノート

反応式

HRID 560345 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:16]([N:18]1[C:22]([C:23](O)=[O:24])=[CH:21][C:20]([CH3:26])=[N:19]1)[CH3:17]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]2[C@H:10]([CH2:11]2)[C@H:9]1[CH2:14][NH:15][C:23]([C:22]1[N:18]([CH2:16][CH3:17])[N:19]=[C:20]([CH3:26])[CH:21]=1)=[O:24])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 27437941-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acidHCID 59444330tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo(3.1.0)hexane-3-carboxylate

生成物 1

HCID 66998581(1S,2S,5R)-2-{[(2-Ethyl-5-methyl-2H-pyrazole-3-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

実験手順

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid. 1H-NMR (CDCl3): δ=0.19 (q, J=4.3 Hz, 1H); 0.73 (dt, J=7.7 Hz, J=5.5 Hz, 1H); 1.30-1.36 (m, 1H); 1.38-1.43 (m, 3H); 1.45 (s, 9H); 1.46-1.53 (m, 1H); 2.24 (s, 3H); 3.34-3.42 (m, 2H); 3.55-3.64 (m, 2H); 4.18 (dd, J=10.8 Hz, J=3.0 Hz, 1H); 4.47-4.62 (m, 2H); 6.36 (s, 1H); 7.76 (bs, 1H).

出典と根拠

ORDレコード
ord-10561e29a9194878971d48bb0ecb8dca
出典データセット
uspto-grants-2011_11
特許番号
US08063099B2

反応ノート

読み込み中…