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HRID 560443作成日：2026年10月26日

1,2-Dimethylindole-3-carboxylic acid → 1,2-Dimethyl-1h-indole-3-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

https://huagongshe.com/reaction/560443

反応式

関与物質

役割名称HCID仕込み量
反応物1,2-Dimethylindole-3-carboxylic acidHCID 2761032—
反応物((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanoneHCID 66998493—
生成物1,2-Dimethyl-1h-indole-3-carboxylic acid{(1s,2s,5r)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amideHCID 25182392—

反応手順

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 1,2-Dimethyl-1H-indole-3-carboxylic acid. LC-MS (basic): tR=0.93 min; [M+H]+=519.3.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08063099B2
出典データセットuspto-grants-2011_11
ORD IDord-d9437f2920de4f6c98da529618aa2eb3
出典メモuspto-grants-2011_11