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HRID 560538作成日：2026年10月27日

N-(2,2-dimethoxyethyl)-N-(4-fluorobenzyl)amine → 2-(3-(2,2-dimethoxyethyl)-3-(4-fluorobenzyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

https://huagongshe.com/reaction/560538

反応式

関与物質

役割名称HCID仕込み量
反応物N-(2,2-dimethoxyethyl)-N-(4-fluorobenzyl)amineHCID 11615438—
反応物2-amino-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamideHCID 62793896—
反応物N-(2,2-dimethoxyethyl)-4-fluoroanilineHCID 63686639—
生成物2-(3-(2,2-dimethoxyethyl)-3-(4-fluorobenzyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamideHCID 8664528469%

反応手順

Following the procedure as described in step B of Preparation 2, making variations as required to replace N-(2,2-dimethoxyethyl)-4-fluoroaniline with N-(4-fluorobenzyl)-2,2-dimethoxyethanamine to react with 2-amino-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide, 2-(3-(2,2-dimethoxyethyl)-3-(4-fluorobenzyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide was obtained in 69% yield: MS (ES+) m/z 488.4 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08063084B2
出典データセットuspto-grants-2011_11
ORD IDord-36338a1fb5574f3c848e5d13a9e44d79
出典メモuspto-grants-2011_11