Sodium Bicarbonate → ethyl 5-amino-3-methylthiophene-2-carboxylate
反応式
Cl.[NH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1.C(=O)(O)[O-].[Na+]>ClCCl>[NH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1参加物
4
実験手順
Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride (5.80 g, 26.2 mmol) was suspended in dichloromethane (200 mL). To the suspension was added saturated aqueous sodium bicarbonate solution (250 mL). The resulting mixture was stirred for 15 minutes, then the two layers were separated. The aqueous layer was extracted with dichloromethane (100 mL). The combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to afford ethyl 5-amino-3-methylthiophene-2-carboxylate (4.75 g, 98%).
後処理
- customthe two layers were separated
- extractionThe aqueous layer was extracted with dichloromethane (100 mL)
- dry with materialThe combined organic layer was dried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-d7b5d4d01461421a8a815c8686523762
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063084B2
反応ノート
読み込み中…