Diethylamine → N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamine

HRID 56078ノート

反応式

HRID 56078 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10].[CH2:11]([NH:13][CH2:14][CH3:15])[CH3:12]>CCO>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10])[CH2:14][CH3:15])[CH3:12]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene

生成物 1

HCID 90022808N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamine収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-(bromomethyl)-2-fluoro-4-iodobenzene (1.89 g, 6.0 mmol) and a solution of diethylamine (2.19 g, 30 mmol) in EtOH (60 mL) was stirred at rt overnight under N2, then concentrated in vacuo. The residue was dissolved in EtOAc (100 mL), and washed with water (100 mL×3) followed by brine (100 mL). The organic phase was concentrated in vacuo to give the title compound as colorless oil (1.72 g, 94%).

後処理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in EtOAc (100 mL)
  3. washwashed with water (100 mL×3)
  4. concentrationThe organic phase was concentrated in vacuo

出典と根拠

ORDレコード
ord-09eac039fcb240d299595f50e5735ec9
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

読み込み中…