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Ethyl Bromide → 2-(4-Ethoxyphenyl)thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Bromide | HCID 6332 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(1,3-Thiazol-2-yl)phenol | HCID 223840 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(4-Ethoxyphenyl)thiazole | HCID 69160608 | 100% |
反応手順
To a mixture of 2-(4-hydroxyphenyl)thiazole (21.27 g, 0.12 mol) and K2CO3 (82.93 g, 0.60 mol) in acetone (1000 mL) was added bromoethane (39.24 g, 0.36 mol) with stirring at rt. The reaction mixture was heated at 60° C. for 11 h, then cooled to rt, filtered and concentrated in vacuo to give the title compound as a white solid (24.54 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-1ffa6d2b914f46358351db5fa944536d |
| 出典メモ | uspto-grants-2016_09 |