Water → (4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride monohydrate

A suspension of crude (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride (2.1 g, 5.2 mmol) in absolute EtOH (30 mL) was heated to 78° C. and H2O (2.2 mL) was added. The resulting solution was cooled to room temperature and MTBE (5 mL) was added. The resulting suspension was cooled to 0° C. and filtered. The filter cake was washed with MeOH (15 mL). The solids were dried in a vacuum oven at 105° C. for 20 h to yield the title compound as a white solid.

1. temperatureThe resulting solution was cooled to room temperature
2. temperatureThe resulting suspension was cooled to 0° C.
3. filtrationfiltered
4. washThe filter cake was washed with MeOH (15 mL)
5. customThe solids were dried in a vacuum oven at 105° C. for 20 h

ORDレコード

ord-4ca859f34b66435ca8dc2d0e99e97e14

出典データセット

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08063206B2