Piperidine → 1-(2-Fluoro-4-nitrophenyl)piperidine
反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CCN(CC)CC.F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=1[F:24]>CCOC(C)=O>[F:24][C:16]1[CH:17]=[C:18]([N+:21]([O-:23])=[O:22])[CH:19]=[CH:20][C:15]=1[N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
To a solution of piperidine (5.88 g, 69 mmol) and Et3N (6.98 g, 69 mmol) in EtOAc (60 mL) was added 1,2-difluoro-4-nitrobenzene (10.00 g, 63 mmol) dropwise. The mixture was stirred at rt overnight. The resulting mixture was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (14.00 g, 99%).
後処理
- washThe resulting mixture was washed with brine
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-e03d6bb1801d42d4b779a7b74f77f155
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434695B2
反応ノート
読み込み中…