Dimethyl Sulfoxide → HCID 67328472、化合物

HRID 561072ノート

反応式

HRID 561072 の反応式
CS(C)=O.[CH3:5]C(C)([O-])C.[Na+].[C:11]([C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:15][CH:14]=1)#[N:12].CC(OC)(C)C>[Cl-].[Na+].O>[C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]2[CH2:5][C@H:20]2[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:15][CH:14]=1)#[N:12]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 15413tert-Butyl methyl etherHCID 11287649Tert-butyl 3-(4-cyanophenyl)prop-2-enoateHCID 23676156Sodium t-butoxide

生成物 1

HCID 67328472HCID 67328472、化合物収率 55.3%

試薬・触媒・溶媒 1

HCID 57417360Sodium chloride; water溶媒

実験手順

A round bottom flask was charged with (CH3)3S(I)O (37.9 g, 172.4 mmol, 2 eq.) and DMSO (450 mL). With moderate stirring under N2, a clear yellow solution was formed. To this solution was added sodium tert-butoxide (16.5 g, 172.4 mmol, 2 eqs) and the resultant mixture was stirred at RT for 2 h. 21A (20 g, 86.2 mmol, 1 eq) was charged and the container of the acrylate was rinsed forward with DMSO (50 mL). Stirring of the reaction mixture was continued at RT for 16 h. The reaction mixture was analyzed for completion using 1H NMR spectroscopy. After confirming completion of the reaction, the reaction mixture was diluted by sequential addition of MTBE (500 mL) and brine (300 mL). The organic layer was separated, dried over MgSO4 and evaporated to dryness to give crude product. The crude product was purified by flash chromatography, eluting with 5-10% EtOAc in heptanes to give 11.6 g 21B (54% yield) (which was found by 1H NMR to contain a small amount of impurities). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.23-1.29 (m, 1H) 1.49 (s, 9H) 1.57-1.69 (m, 1H) 1.83-1.96 (m, 1H) 2.40-2.53 (m, 1H), 7.18 (d, 2H) 7.56 (d, 2H).

後処理

  1. customa clear yellow solution was formed
  2. washthe container of the acrylate was rinsed forward with DMSO (50 mL)
  3. stirringStirring of the reaction mixture
  4. customcompletion of the reaction
  5. customThe organic layer was separated
  6. dry with materialdried over MgSO4
  7. customevaporated to dryness
  8. customto give crude product
  9. customThe crude product was purified by flash chromatography
  10. washeluting with 5-10% EtOAc in heptanes

出典と根拠

ORDレコード
ord-863eee44ae4144fb996644fd77715a1f
出典データセット
uspto-grants-2011_11
特許番号
US08063215B2

反応ノート

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