関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| 反応物 | Benzenecarbothioamide, 4-(diethylamino)- | HCID 28410527 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N,N-diethyl-4-(thiazol-2-yl)aniline | HCID 20471151 | 55% |
反応手順
To a solution of 4-(diethylamino)benzothioamide (2.29 g, 11 mmol) in EtOH (60 mL) were added 2-bromo-1,1-dimethoxyethane (1.86 g, 11 mmol) and p-toluenesulfonic acid (1.89 g, 11 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc/Et3N (V/V/V)=2:1:0.05) to give the title compound as a white solid (1.40 g, 55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09434695B2 |
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| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-ac4c8fb978c34e78bf800f3165254691 |
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| 出典メモ | uspto-grants-2016_09 |
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