Benzylamine → Ethyl 3-(benzylamino)-3-methylbutanoate

HRID 561118

反応式

HRID 561118 の反応式
[CH3:1][C:2]([CH3:9])=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CCO>[CH2:10]([NH:17][C:2]([CH3:9])([CH3:1])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 12516Ethyl 3,3-dimethylacrylate

生成物 1

HCID 288946Ethyl 3-(benzylamino)-3-methylbutanoate収率 21.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 3,3-dimethylacrylate (19.3 g, 0.151 mol) in EtOH (150 mL) was added benzylamine (16.2 g, 0.151 mol) and refluxed for 24 h. The reaction mixture was concentrated in vacuo. The distillation of the residue gave ethyl 3-benzylamino-3-methylbutyrate as a colorless oil (7.48 g, 21%).

後処理

  1. temperaturerefluxed for 24 h
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. distillationThe distillation of the residue

出典と根拠

ORDレコード
ord-319b932dd8ae4c888979a6e751abcd91
出典データセット
uspto-grants-2011_11
特許番号
US08063221B2

関連ノート

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