関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lawesson's reagent | HCID 87949 | — |
| 反応物 | 4-(Morpholin-4-yl)benzamide | HCID 22142242 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Morpholinobenzenecarbothioamide | HCID 2795360 | 83.4% |
反応手順
To a solution of 4-morpholinobenzamide (4.91 g, 23.80 mmol) in THF (70 mL) was added Lawesson's Reagent (10.60 g, 26.20 mmol) with stirring. The mixture was heated at 70° C. for 4 h, then cooled to rt and concentrated in vacuo. CH2Cl2 (30 mL) and water (100 mL) was added to the residue. The mixture was then filtered and the filter cake was washed with water and dried to give the title compound as a yellow solid (4.41 g, 83.3%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434695B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-b3263675a8b3462c97d4844f0524773b |
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| 出典メモ | uspto-grants-2016_09 |
|---|
