関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| 反応物 | 4-Morpholinobenzenecarbothioamide | HCID 2795360 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(4-(Thiazol-2-yl)phenyl)morpholine | HCID 90022867 | 81.2% |
反応手順
To a solution of 4-morpholinobenzothioamide (2.22 g, 10 mmol) in EtOH (50 mL) were added 2-bromo-1,1-dimethoxyethane (1.69 g, 10 mmol) and p-toluenesulfonic acid (1.90 g, 10 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and filtered. The filter cake was dried to give the title compound as a yellow solid (2.00 g, 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434695B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-f1d7e3e5dde646d382393bff6ab00702 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
