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Water → 4'-[(4-Methylcyclohexylamino)methyl]biphenyl-3-carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Methylcyclohexylamine | HCID 80604 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 4'-Formyl-3-biphenylcarboxamide | HCID 59316529 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4'-[(4-Methylcyclohexylamino)methyl]biphenyl-3-carboxylic acid amide | HCID 25212824 | — |
反応手順
To a solution of 4′-formylbiphenyl-3-carboxylic acid amide (700 mg, 3.1 mmol) in methanol (15 mL) was added 4 Å molecular sieves (700 mg) and 4-methylcyclohexylamine (421 mg, 3.7 mmol). The mixture was stirred for 16 h before adding sodium borohydride (588 mg, 15.5 mmol). After 1 h water (10 mL) was added, the mixture was filtered through celite and the solvent removed in vacuo. Purification of the residue by column chromatography (0.5% NH3: 6% MeOH: DCM) gave the title compound: RT=2.53 min; m/z (ES+)=323.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063247B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-fdfd0688c00c4d4cbba2615508c03b73 |
| 出典メモ | uspto-grants-2011_11 |