Phenethylamine → 4-Fluoro-3-[5-(phenethylaminomethyl)pyridin-2-yl]benzamide

反応式

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][N:12]=1.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][NH:27][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:13][N:12]=1

参加物

反応物 2

HCID 1001Phenethylamine

HCID 595448574-Fluoro-3-(5-formylpyridin-2-yl)benzamide

生成物 1

HCID 252165794-Fluoro-3-[5-(phenethylaminomethyl)pyridin-2-yl]benzamide

実験手順

Using the method outlined in Example 60, 4-fluoro-3-(5-formylpyridin-2-yl)benzamide (Preparation 13) and phenethylamine were converted to the title compound: RT=2.30 min; m/z (ES+)=350.0 [M+H]+.

出典と根拠

ORDレコード: ord-cd6b47b754804febb5f485c6bdd93f4b
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08063247B2

反応ノート

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