3-Bromoadamantane-1-carboxylic acid → HCID 15982549、化合物

HRID 561365

反応式

HRID 561365 の反応式
Br[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([C:12]([OH:14])=[O:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Al+3].[Cl-:16].[Cl-].[Cl-]>ClC1C=CC=CC=1>[Cl:16][C:2]1[CH:11]=[CH:6][C:5]([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][C:4]([C:12]([OH:14])=[O:13])([CH2:5]4)[CH2:3]2)[CH2:9]3)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 308183-Bromoadamantane-1-carboxylic acidHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 15982549HCID 15982549、化合物収率 158.3%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒2 回

実験手順

Over a 30 minute period, 3-bromo-adamantane-1-carboxylic acid (2) (16.0 g, 61.7 mmol) in 50 ml of dry chlorobenzene at −10° C. was added to 100 ml dry chlorobenzene and 9.3 g, 70 mmol AlCl3. The mixture was then warmed to room temperature for 1 hour and then heated to 90° C. for 10 hours. The mixture was then poured onto 200 g of crushed ice, and the filtered to provide 14.2 g (yield=79.3%) of 3-(4-chloro-phenyl)-adamantane-1-carboxylic acid (3).

後処理

  1. temperatureheated to 90° C. for 10 hours
  2. filtrationthe filtered

出典と根拠

ORDレコード
ord-0e58062e6bd941da84466ff550d705b3
出典データセット
uspto-grants-2011_11
特許番号
US08063248B2

関連ノート

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