Sodium Methoxide → 7-[(Methylsulfanyl)methyl]-1H-indole
反応式
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][C:15]=2[CH2:17][S:18][CH3:19])[CH:10]=[CH:9]1)=O)(C)(C)C.C[O-].[Na+]>CO>[CH3:19][S:18][CH2:17][C:15]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:16]=1[NH:8][CH:9]=[CH:10]2参加物
4
実験手順
1.16 g (4.18 mmol) of the compound from Example 7A were introduced into 23 ml of methanol, 26 ml (113 mmol) of a 25% strength methanolic sodium methanolate solution were added, and the mixture was stirred at RT overnight. Then ice-water was added, and the mixture was extracted with dichloromethane. The organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate gradient) to result in 549 mg (74% of theory) of the title compound.
後処理
- additionwere added
- extractionthe mixture was extracted with dichloromethane
- dry with materialThe organic phase was dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate gradient)
出典と根拠
- ORDレコード
- ord-b9c1050cb38e45e789e8595762e561af
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063234B2
反応ノート
読み込み中…