Ethyl 3-(4-chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate → Ethyl 3-(1-benzothiophen-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate

HRID 561408ノート

反応式

HRID 561408 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:21]3[C:29]4[C:24](=[C:25]([CH2:30][S:31][CH3:32])[CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH:11]3C(=O)O[C:14](C)([CH3:18])[O:13][C:12]3=[O:20])=[CH:9][C:4]=2[CH:3]=[CH:2]1.ClC1C=CC(C(C2C3C(=C(CSC)C(F)=CC=3)NC=2)CC(OCC)=O)=CC=1>>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:21]3[C:29]4[C:24](=[C:25]([CH2:30][S:31][CH3:32])[CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH2:11][C:12]([O:13][CH2:14][CH3:18])=[O:20])=[CH:9][C:4]=2[CH:3]=[CH:2]1

参加物

3

反応物 2

HCID 58392255Ethyl 3-(4-chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoateHCID 583922775-[(1-Benzothiophen-5-yl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

生成物 1

HCID 58392303Ethyl 3-(1-benzothiophen-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate

実験手順

The title compound was prepared starting from 1.73 g (71% purity, 3.72 mmol) of the compound from Example 23A in analogy to the synthesis of the compound from Example 47A. 1.23 g (81% of theory) of the title compound were obtained.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-598af0dd01204ca3ab284ec9ca56c555
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…