化工社化工社 化学情報印刷レポート · 研究参考用
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| 反応物 | Acetopiperone | HCID 76622 | — |
| 反応物 | HCID 178418630 | HCID 178418630 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol | HCID 58392261 | — |
反応手順
The title compound was prepared starting from 1.50 g (9.14 mmol) of 3,4-(methylenedioxy)acetophenone and 36.5 ml (18.28 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.32 g (70% of theory) of the title compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063234B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-83377f42d1354a9da6ac332978b01b77 |
| 出典メモ | uspto-grants-2011_11 |