1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol → 1-(4-Amino-2-fluorophenyl)piperidin-4-ol

HRID 56153

反応式

HRID 56153 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1>CO.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]2)=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 1

HCID 265982211-(2-Fluoro-4-nitrophenyl)piperidin-4-ol

生成物 1

HCID 289725861-(4-Amino-2-fluorophenyl)piperidin-4-ol収率 108.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-(2-fluoro-4-nitrophenyl)piperidin-4-ol (2.67 g, 11 mmol) in MeOH (100 mL) was added catalyst Pd/C (1.00 g). The reaction mixture was stirred at rt under H2 for 6 h, then filtered. The filtrate was concentrated in vacuo to give the crude product (2.50 g) for the next step without further purification.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-144c800e0cda4e159c90c2438879491e
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

読み込み中…