CS(O[CH2:6][CH:7]([CH3:28])[CH:8]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)[C:9]1[C:17]2[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)(=O)=O.Br[C:30]1SC(C(C2C3C(=C(CSC)C=CC=3)NC=2)CCC#N)=C[N:34]=1>CS(C)=O>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH:8]([C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[CH:7]([CH3:28])[CH2:6][C:30]#[N:34])=[CH:22][CH:23]=1The title compound was prepared starting from 215 mg (0.49 mmol) of the compound from Example 71A in analogy to the synthesis of the compound from Example 53, but with dimethyl sulfoxide as solvent. 177 mg (98% of theory) of the target compound were obtained as mixture of diastereomers.
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