1-Cyclopropyl-1-(2,4-difluorophenyl)ethanol → 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561579ノート

反応式

HRID 561579 の反応式
ClC1C=C(Cl)C=CC=1C([C:13]1[C:21]2[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[C:19](F)[CH:20]=2)[NH:15][CH:14]=1)CCO.[CH:26]1([C:29]([C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:33]=2[F:39])(O)[CH3:30])[CH2:28][CH2:27]1.C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC(F)=CC=2)C)CC1>>[CH:26]1([C:29]([C:13]2[C:21]3[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)([C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:33]=2[F:39])[CH3:30])[CH2:28][CH2:27]1

参加物

4

反応物 3

HCID 247496791-Cyclopropyl-1-(2,4-difluorophenyl)ethanolHCID 583921063-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923053-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

生成物 1

HCID 583923223-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole

実験手順

The title compound was prepared starting from 500 mg (2.82 mmol) of the compound from Example 8 and 615 mg (3.10 mmol) of the compound from Example 78A in analogy to the synthesis of the compound from Example 95. 227 mg (94% purity, 21% of theory) of the target compound were obtained.

後処理

  1. custom227 mg (94% purity, 21% of theory) of the target compound were obtained

出典と根拠

ORDレコード
ord-5872915fca674e66b19df19edad8cc3e
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…