3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chloro-2-fluorophenyl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole
反応式
ClC1C=C(Cl)C=CC=1C([C:13]1[C:21]2[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[C:19](F)[CH:20]=2)[NH:15][CH:14]=1)CCO.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([CH:36]2[CH2:38][CH2:37]2)(O)[CH3:34])=[C:29]([F:39])[CH:28]=1.C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC(F)=CC=2)C)CC1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:13]2[C:21]3[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:34])=[C:29]([F:39])[CH:28]=1参加物
4
反応物 3
生成物 1
反応条件
- 温度
- 0 °C