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Cesium carbonate → 3-chloro-N-(2-morpholinoethyl)-4-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2,4-Dichloronitrobenzene | HCID 11899 | — |
| 反応物 | 2-Morpholinoethylamine | HCID 408285 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-chloro-N-(2-morpholinoethyl)-4-nitroaniline | HCID 90023325 | 50.4% |
反応手順
A suspension of 2-morpholinoethanamine (5.34 g, 41 mmol), 2,4-dichloro-1-nitrobenzene (7.87 g, 41 mmol) and Cs2CO3 (26.73 g, 82 mmol) in acetonitrile (100 mL) was refluxed for 6 h under N2, then cooled to rt, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as a yellow solid (5.90 g, 50%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-45406502a7e94b2580c3119a7d6c8476 |
| 出典メモ | uspto-grants-2016_09 |