7-[(Methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561641ノート

反応式

HRID 561641 の反応式
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([C:16]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)(O)[CH2:17][CH3:18])[CH2:15][CH2:14]1.C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC(OC)=C(F)C=2)C)CC1>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:16]([C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH3:18])=[CH:21][CH:22]=1

参加物

4

反応物 3

HCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583923303-[1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583925071-Cyclopropyl-1-(4-chlorophenyl)propanol

生成物 1

HCID 583921183-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole

実験手順

The title compound was prepared starting from 84 mg (0.48 mmol) of the compound from Example 8A and 100 mg (0.48 mmol) of the compound from Example 145A in analogy to the synthesis of the compound from Example 186. 38 mg (21% of theory) of the target compound were obtained.

後処理

  1. custom38 mg (21% of theory) of the target compound were obtained

出典と根拠

ORDレコード
ord-6b98884d3c924f6f9e7ed9854d2eac07
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…