3-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole
反応式
[S:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)(C3CC3)C)=CC=2[CH:3]=[CH:2]1.Cl[C:28]1[CH:33]=[CH:32][C:31]([C:34]([C:39]2[C:47]3[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=3)[NH:41][CH:40]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:35])=[CH:30][CH:29]=1>>[S:1]1[C:28]2[CH:29]=[CH:30][C:31]([C:34]([C:39]3[C:47]4[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=4)[NH:41][CH:40]=3)([CH:36]3[CH2:37][CH2:38]3)[CH3:35])=[CH:32][C:33]=2[CH:3]=[CH:2]1参加物
3
実験手順
The title compound was prepared starting from 237 mg (0.63 mmol) of the compound from Example 187 in analogy to the synthesis of the compound from Example 209. 144 mg (56% of theory) of the target compound were obtained.
後処理
- custom144 mg (56% of theory) of the target compound were obtained
出典と根拠
- ORDレコード
- ord-5181c7d0b7b241b592275897dd7b99ac
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063234B2
反応ノート
読み込み中…