3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole
反応式
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC3[O:10][C:11]([F:14])([F:13])[O:12]C=3C=2)C)CC1.Cl[C:30]1[CH:35]=[CH:34][C:33]([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([CH:38]2[CH2:40][CH2:39]2)[CH3:37])=[CH:32][CH:31]=1>>[CH:38]1([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([C:33]2[CH:34]=[CH:35][C:30]3[O:10][C:11]([F:14])([F:13])[O:12][C:31]=3[CH:32]=2)[CH3:37])[CH2:40][CH2:39]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared starting from 33 mg (0.08 mmol) of the compound from Example 190 in analogy to the synthesis of the compound from Example 209. 27 mg (76% of theory) of the target compound were obtained.