Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol → 3-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561663ノート

反応式

HRID 561663 の反応式
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([CH:16]([C:18]2[CH:28]=[CH:27][C:21]3[O:22][C:23]([F:26])([F:25])[O:24][C:20]=3[CH:19]=2)O)[CH2:15][CH2:14]1.ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[CH:13]1([CH:16]([C:18]2[CH:28]=[CH:27][C:21]3[O:22][C:23]([F:25])([F:26])[O:24][C:20]=3[CH:19]=2)[C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)[CH2:14][CH2:15]1

参加物

4

反応物 3

HCID 58392116Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanolHCID 583921383-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indole

生成物 1

HCID 583923293-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

実験手順

The title compound was prepared starting from 500 mg (2.82 mmol) of the compound from Example 8A and 644 mg (2.82 mmol) of the compound from Example 157A in analogy to the synthesis of the compound from Example 227. A difference was that stirring at RT was for 45 min. 661 mg (60% of theory) of the target compound were obtained.

後処理

  1. custom661 mg (60% of theory) of the target compound were obtained

出典と根拠

ORDレコード
ord-eee986084b0a4d77bd32c25c06ff5cbf
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…