3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole

HRID 561664ノート

反応式

HRID 561664 の反応式
[F:1]C1C=C2C(=C(CSC)C=1)NC=C2.[Cl:14][C:15]1[CH:20]=[C:19](F)[C:18](C(C2CC2)O)=[C:17]([F:27])[CH:16]=1.ClC1C=CC([CH:35]([CH:48]2[CH2:50][CH2:49]2)[C:36]2[C:44]3[C:39](=[C:40]([CH2:45][S:46][CH3:47])[CH:41]=[CH:42][CH:43]=3)[NH:38][CH:37]=2)=CC=1>>[Cl:14][C:15]1[CH:16]=[C:17]([F:27])[CH:18]=[CH:19][C:20]=1[CH:35]([CH:48]1[CH2:49][CH2:50]1)[C:36]1[C:44]2[C:39](=[C:40]([CH2:45][S:46][CH3:47])[CH:41]=[C:42]([F:1])[CH:43]=2)[NH:38][CH:37]=1

参加物

4

反応物 3

HCID 583921383-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583922275-Fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 58392245(4-Chloro-2,6-difluorophenyl)(cyclopropyl)methanol

生成物 1

HCID 583924223-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole

実験手順

The title compound was prepared starting from 200 mg (1.02 mmol) of the compound from Example 11A and 206 mg (1.02 mmol) of the compound from Example 156A in analogy to the synthesis of the compound from Example 227. 247 mg (64% of theory) of the target compound were obtained.

後処理

  1. custom247 mg (64% of theory) of the target compound were obtained

出典と根拠

ORDレコード
ord-75be6ef4c98644fbb6c6807574c0d6b1
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…