4-Chloro-alpha-cyclopropylbenzenemethanol → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole
反応式
[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH:14]1([CH:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)O)[CH2:16][CH2:15]1.ClC1C=C(F)C=CC=1C(C1CC1)C1C2C(=C(CSC)C(F)=CC=2)NC=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([CH:17]([CH:14]2[CH2:15][CH2:16]2)[C:6]2[C:5]3[C:9](=[C:10]([CH2:11][S:12][CH3:13])[C:2]([F:1])=[CH:3][CH:4]=3)[NH:8][CH:7]=2)=[CH:20][CH:21]=1参加物
4
反応物 3
生成物 1
実験手順
The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 9A and 468 mg (2.56 mmol) of the compound from Example 153A in analogy to the synthesis of the compound from Example 233. 411 mg (44% of theory) of the target compound were obtained.
後処理
- custom411 mg (44% of theory) of the target compound were obtained
出典と根拠
- ORDレコード
- ord-2239be35a4a0473888e3f35ed2732490
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063234B2
反応ノート
読み込み中…