3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole
反応式
[CH:1]1([CH:4]([C:17]2[CH:27]=[CH:26][C:20]3[O:21][C:22]([F:25])([F:24])[O:23][C:19]=3[CH:18]=2)[C:5]2[C:13]3[C:8](=[C:9]([CH2:14][S:15][CH3:16])[CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)[CH2:3][CH2:2]1.ClC1C=CC(C(C2CC2)C2C3C(=C(CS(C)=[O:47])C=CC=3)NC=2)=CC=1>>[CH:1]1([CH:4]([C:17]2[CH:27]=[CH:26][C:20]3[O:21][C:22]([F:25])([F:24])[O:23][C:19]=3[CH:18]=2)[C:5]2[C:13]3[C:8](=[C:9]([CH2:14][S:15]([CH3:16])=[O:47])[CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)[CH2:2][CH2:3]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared starting from 100 mg (0.26 mmol) of the compound from Example 231 in analogy to the synthesis of the compound from Example 235. 92 mg (88% of theory) of the target compound were obtained as mixture of diastereomers.
後処理
- custom92 mg (88% of theory) of the target compound were obtained as mixture of diastereomers
出典と根拠
- ORDレコード
- ord-f98ad73fb1914f86887cc4857a33f453
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063234B2
反応ノート
読み込み中…