3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561722ノート

反応式

HRID 561722 の反応式
ClC1C=CC(C(C2C=C[C:24]([O:27]C)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54](Cl)=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54]([O:27][CH3:24])=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1

参加物

3

反応物 2

HCID 583923823-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583924453-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

生成物 1

HCID 583924833-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

実験手順

The title compound was prepared starting from 150 mg (0.37 mmol) of the compound from Example 282 in analogy to the synthesis of the compound from Example 312. 130 mg (80% of theory) of the target compound were obtained.

後処理

  1. custom130 mg (80% of theory) of the target compound were obtained

出典と根拠

ORDレコード
ord-4d3bad5181b441509b5a26efbe1198ee
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

反応ノート

読み込み中…