Hexylamine → 2-Fluoro-n-hexyl-4-nitroaniline

HRID 56177

反応式

HRID 56177 の反応式
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.CCN(CC)CC.[CH2:19]([NH2:25])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>CCOC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[NH:25][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

参加物

5

反応物 3

HCID 8102HexylamineHCID 8471TriethylamineHCID 1230531,2-Difluoro-4-nitrobenzene

生成物 1

HCID 5980562-Fluoro-n-hexyl-4-nitroaniline収率 91%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3,4-difluoronitrobenzene (3.18 g, 20 mmol) in EtOAc (50 mL) were added Et3N (2.43 g, 24 mmol) and hexan-1-amine (2.02 g, 20 mmol). The reaction mixture was refluxed overnight, then cooled to rt and concentrated in vacuo to give the title compound as yellow oil (4.37 g, 91%).

後処理

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2ba673d1d82046bf98c0437cb95eb1a4
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

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