Sulfuryl chloride → 2-Chloro-3-hydroxy-5-(3-methoxypropyl)benzaldehyde
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:9]=1)[CH:5]=[O:6].S(Cl)([Cl:18])(=O)=O>ClCCl>[Cl:18][C:3]1[C:2]([OH:1])=[CH:9][C:8]([CH2:10][CH2:11][CH2:12][O:13][CH3:14])=[CH:7][C:4]=1[CH:5]=[O:6]参加物
4
実験手順
To a solution of 3-hydroxy-5-(3-methoxypropyl)benzaldehyde from the previous step (I eq.) in dichloromethane (0.2 M) was added sulfuryl chloride (1 eq.). The resulting reaction mixture was then stirred at RT for 18 h. The volatiles were removed in vacuo and purification of the crude product thus obtained by way of column chromatography (SiO2, Hex→3:2 (v/v) Hex:EtOAc) afforded the title compound as a yellow oil.
後処理
- customThe resulting reaction mixture
- customThe volatiles were removed in vacuo and purification of the crude product
- customthus obtained by way of column chromatography (SiO2, Hex→3:2 (v/v) Hex:EtOAc)
出典と根拠
- ORDレコード
- ord-d0a826634e2041c2b467da77ad815ef4
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063105B2
反応ノート
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