Potassium Carbonate → 2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

HRID 56187

反応式

HRID 56187 の反応式
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].F[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=1[F:26]>CC(C)=O>[F:26][C:18]1[CH:19]=[C:20]([N+:23]([O-:25])=[O:24])[CH:21]=[CH:22][C:17]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 33944N-(2-Aminoethyl)piperidineHCID 1230531,2-Difluoro-4-nitrobenzene

生成物 1

HCID 523235752-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 2-(piperidin-1-yl)ethanamine (0.90 g, 7.02 mmol) and K2CO3 (0.97 g, 7.02 mmol) in acetone (30 mL) was added 1,2-difluoro-4-nitrobenzene (1.11 g, 6.98 mmol) in one portion in an ice bath and the mixture was refluxed overnight, cooled to rt and filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for next step without further purification.

後処理

  1. temperaturethe mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-21db24e4e1534aff9214e05e442c933c
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

読み込み中…