Hydrochloric Acid → 3-Amino-N-{[5-chloro-2-(methoxypropyl)-1-oxidopyridin-4-yl]methyl}-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanamide

HRID 561883ノート

反応式

HRID 561883 の反応式
[Cl:1][C:2]1[C:3]([CH2:14][N:15]([CH:48]2[CH2:50][CH2:49]2)[C:16](=[O:47])[CH:17]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][O:37][C:38]3[C:43]([Cl:44])=[CH:42][C:41]([CH3:45])=[CH:40][C:39]=3[Cl:46])=[CH:30][CH:29]=2)[CH2:18][NH:19]C(=O)OC(C)(C)C)=[CH:4][C:5]([CH2:9][CH2:10][CH2:11][O:12][CH3:13])=[N+:6]([O-:8])[CH:7]=1.Cl>C(Cl)Cl>[NH2:19][CH2:18][CH:17]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][O:37][C:38]2[C:43]([Cl:44])=[CH:42][C:41]([CH3:45])=[CH:40][C:39]=2[Cl:46])=[CH:30][CH:29]=1)[C:16]([N:15]([CH2:14][C:3]1[C:2]([Cl:1])=[CH:7][N+:6]([O-:8])=[C:5]([CH2:9][CH2:10][CH2:11][O:12][CH3:13])[CH:4]=1)[CH:48]1[CH2:50][CH2:49]1)=[O:47]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 91035818HCID 91035818、化合物

生成物 1

HCID 159811813-Amino-N-{[5-chloro-2-(methoxypropyl)-1-oxidopyridin-4-yl]methyl}-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a CH2Cl2 solution (0.07 M) of tert-butyl (3-[{[5-chloro-2-(methoxypropyl)-1-oxidopyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from the previous step (1 eq.) was added HCl (4.0 M dioxane solution, 30 eq.). The resulting solution was stirred at RT for 16 h. Following the removal of the volatiles in vacuo, the resulting residue was directly subjected to column chromatography (SiO2, 95:5 (v/v) CH2Cl2: 2.0 M NH3 in MeOH) to afford the title compound as an oil. MS (ESI+): 651.

後処理

  1. customthe removal of the volatiles in vacuo

出典と根拠

ORDレコード
ord-4261ab71dd824d9599905af6b70d1698
出典データセット
uspto-grants-2011_11
特許番号
US08063105B2

反応ノート

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