1-(2-Fluoro-4-iodo-phenyl)-ethanol → 2'-Fluoro-4'-iodoacetophenone

HRID 561962ノート

反応式

HRID 561962 の反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:11])[CH3:10]>ClCCl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]

参加物

4

反応物 1

HCID 534154531-(2-Fluoro-4-iodo-phenyl)-ethanol

生成物 1

HCID 534154542'-Fluoro-4'-iodoacetophenone収率 91.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 58.26 mmol) in dichloromethane (250 mL) was added manganese dioxide (101.26 g, 1.17 mole) and the reaction mixture was heated to reflux for 24 hours. The reaction mixture was cooled, filtered through a pad of celite coated with a thin layer of silica gel and concentrated in vacuo to give 1-(2-fluoro-4-iodo-phenyl)-ethanone (14.04 g, 91%).

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered through a pad of celite coated with a thin layer of silica gel
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b0979d46b68d4c4dbb22e9005ec959b9
出典データセット
uspto-grants-2011_11
特許番号
US08063085B2

反応ノート

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