But-1-ene-1,3-dione → N-(3-chloro-4-(dihexylamino)phenyl)-3-oxobutanamide

HRID 56198ノート

反応式

HRID 56198 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[C:22]([CH:25]=[C:26]=[O:27])(=[O:24])[CH3:23]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:26](=[O:27])[CH2:25][C:22](=[O:24])[CH3:23])[CH:5]=[CH:4][C:3]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 12642904But-1-ene-1,3-dioneHCID 1179660622-chloro-N1,N1-dihexylbenzene-1,4-diamine

生成物 1

HCID 90023042N-(3-chloro-4-(dihexylamino)phenyl)-3-oxobutanamide収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

To a solution of 2-chloro-N1,N1-dihexylbenzene-1,4-diamine (3.11 g, 10 mmol) in toluene (50 mL) was added acetyl ketene (1.68 g, 20 mmol) and the mixture was stirred at 80° C. overnight. The mixture was cooled to rt and concentrated in vacuo to give the title compound as blackish oil (3.94 g, 100%).

後処理

  1. temperatureThe mixture was cooled to rt
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-51ab07dd89b54868b4347755c0f77952
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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