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Chlorosuccinimide → HCID 178432845、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | 3-((R)-1-{(S)-1-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2,5-dioxo-imidazolidin-4-yl)-propionic acid | HCID 57771978 | — |
| 反応物 | (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid | HCID 66815126 | — |
| 反応物 | HCID 178432851 | HCID 178432851 | — |
| 生成物 | HCID 178432845 | HCID 178432845 | — |
反応手順
Prepared by the same method as described in example 1 except that (i) steps A, B and C were omitted; (ii) 1-(2-fluoro-4-iodo-phenyl)-propan-1-one (prepared as described in example 13) was used in place of 1-(2-fluoro-4-iodo-phenyl)-ethanone in step 59-D; (iii) (S)-2-tert-butoxycarbonylamino-3-methylbutyric acid was used in place of (2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 59-E and (iv) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 59-F was omitted. HR-MS: calcd for C25H26FlN4O4 [M+H+] 593.1056. Found 593.1052.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063085B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-f13b41b9e5c1467791e3e90799b8f951 |
| 出典メモ | uspto-grants-2011_11 |